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M106 or M-106 may refer to:
- M106 (New York City bus), a New York City Bus route in Manhattan
- M-106 (Michigan highway), a state highway in Michigan
- BMW M106, a motor
- Messier 106, a spiral galaxy about in the constellation Canes Venatici
- Klimov VK-106 or M-106 aircraft engine
- M106 mortar carrier a tracked, self-propelled artillery vehicle formerly in service with the United States Army
| disambiguation page lists articles associated with the same title formed as a letter-number combination.
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